{"product_id":"cst-33483s","title":"CST,  33483S, BOB-1\/OBF-1 Antibody","description":"Polyclonal Antibody for studying POU2AF1. Validated for Western Blotting. Highly specific and rigorously validated in-house, BOB-1\/OBF-1 Antibody (CST #33483) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nBOB-1\/OBF-1 Antibody recognizes endogenous levels of total BOB-1\/OBF-1 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro209 of human BOB-1\/OBF-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nB cell Oct binding factor-1 (BOB-1\/OBF-1) is a B cell restricted transcriptional coactivator. BOB-1 facilitates transactivation of immunoglobulins and other B cell specific genes through the binding and activation of the transcription factors Oct-1 and Oct-2 (1-4). Research studies have demonstrated that BOB-1 expression is required for antigen-dependent B cell maturation (5-7). In pathological conditions such as classical Hodgkin disease, loss of BOB-1 expression is thought, in part, to contribute to the defect in immunoglobulin gene expression by Hodgkin and Reed Sternberg cells (8,9). In the context of multiple myeloma, overexpression of BOB-1 has been shown to contribute to malignant plasma cell growth, in part, through enhanced transactivation of (10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nB-cell-specific coactivator OBF-1; BOB-1; BOB1; OBF-1; OBF1; OCA-B; OCAB; OCT-binding factor 1; POU class 2 associating factor 1; POU class 2 homeobox associating factor 1; POU domain class 2-associating factor 1; POU domain, class 2, associating factor 1; POU2AF1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 35\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46800985161897,"sku":"33483S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-33483s","provider":"Iright","version":"1.0","type":"link"}