{"product_id":"cst-33750s","title":"CST,  33750S, ZAP (E5V4D) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ZAP. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, ZAP (E5V4D) Rabbit Monoclonal Antibody (CST #33750) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nZAP (E5V4D) Rabbit Monoclonal Antibody recognizes endogenous levels of total ZAP protein. This antibody recognizes ZAP isoforms 1 and 2.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp210 of human ZAP protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nZAP (Zinc finger CCCH-type antiviral protein 1, ZC3HAV1, PARP13) is an RNA-binding protein which inhibits the replication of certain viruses, including HIV-1, by preventing the accumulation of viral RNA in the cytoplasm (1-5). ZAP binds to specific viral mRNAs through the CCCH zinc finger motifs located on its N terminus, and recruits exosomes and decapping enzymes to degrade the target RNA (3-5). ZAP also interferes with the interaction between eIF4A and eIF4G on target mRNA, causing translational repression (6). Isoform 2, the shorter isoform also known as ZAPS, acts as a stimulator of interferon responses in human cells mediated by the RNA helicase RIG-I as part of the innate antiviral immune response (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; CCCH-type zinc finger antiviral protein; DKFZp686F2052; DKFZp686H1869; DKFZp686O19171; FLB6421; FLJ13288; Inactive Poly [ADP-ribose] polymerase 13; MGC48898; PARP13; ZAP; ZC3H2; ZC3HAV1; ZC3HDC2; ZCCHV; Zinc finger antiviral protein; Zinc finger CCCH domain-containing protein 2; zinc finger CCCH type, antiviral 1; Zinc finger CCCH-type antiviral protein 1; zinc finger CCCH-type containing, antiviral 1; zinc finger CCCH-type, antiviral 1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 80, 100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800987291817,"sku":"33750S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-33750s","provider":"Iright","version":"1.0","type":"link"}