{"product_id":"cst-33942t","title":"CST,  33942T, SWAP70 (D5O6A) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SWAP70. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, SWAP70 (D5O6A) Rabbit Monoclonal Antibody (CST #33942) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSWAP70 (D5O6A) Rabbit Monoclonal Antibody recognizes endogenous levels of total SWAP70 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp536 of human SWAP70 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSWAP70 is a Rac family guanine nucleotide exchange factor (GEF) (1). It is highly expressed by activated B cells. Following B cell stimulation, SWAP70 has been observed to translocate from the cytoplasm to the nucleus, where it plays a role in class switching, as well as to the membrane, where it associates with the B cell receptor (2,3). SWAP70 also plays a role in migration of B cells and other immune cell types including dendritic cells, eosinophils, and mast cells (4-7). Mice deficient in both SWAP70 and a related protein, DEF6, develop lupus-like autoimmunity due to misregulation of IRF4 in B cells and T cells leading to increased IL21 production and responsiveness (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ39540; HSPC321; KIAA0640; SWAP switching B-cell complex 70kDa subunit; SWAP switching B-cell complex subunit 70; SWAP-70; SWAP70; Switch-associated protein 70; switching B cell complex subunit SWAP70; SWP70\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 70, 74\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800989159593,"sku":"33942T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-33942t","provider":"Iright","version":"1.0","type":"link"}