{"product_id":"cst-34214t","title":"CST,  34214T, CNOT2 (D8Z8P) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CNOT2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, CNOT2 (D8Z8P) Rabbit Monoclonal Antibody (CST #34214) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCNOT2 (D8Z8P) Rabbit Monoclonal Antibody recognizes endogenous levels of total CNOT2 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CNOT2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe evolutionarily conserved CCR4-NOT (CNOT) complex regulates mRNA metabolism in eukaryotic cells (1). This regulation occurs at different levels of mRNA synthesis and degradation, including transcription initiation, elongation, deadenylation, and degradation (1). Multiple components, including CNOT1, CNOT2, CNOT3, CNOT4, CNOT6, CNOT6L, CNOT7, CNOT8, CNOT9, and CNOT10 have been identified in this complex (2). In addition, subunit composition of this complex has been shown to vary among different tissues (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex, subunit 2; CDC36; CNOT2; FLJ26456; HSPC131; IDNADFS; negative regulator of transcription 2; NOT2; NOT2 (negative regulator of transcription 2, yeast) homolog; NOT2H\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 62\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799417114793,"sku":"34214T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-34214t","provider":"Iright","version":"1.0","type":"link"}