{"product_id":"cst-3432s","title":"CST,  3432S, Cytokine Receptor Common beta-Chain Antibody","description":"Polyclonal Antibody for studying CSF2RB. Validated for Western Blotting. Highly specific and rigorously validated in-house, Cytokine Receptor Common beta-Chain Antibody (CST #3432) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCytokine Receptor Common beta-Chain Antibody detects endogenous levels of total cytokine receptor common beta-chain protein independent of phosphorylation.\nSpecies Reactivity: Human, Mouse, Rat, Monkey, Mink\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human cytokine receptor common beta-chain. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe common beta-chain (beta-c) of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors is the major signaling subunit of these receptors, coupling ligand binding to multiple biological activities (1-3). Tyrosine phosphorylation of cytokine receptor common beta-chain is one of the first events in GM-CSF, IL-3, and IL-5 receptor activation and in signaling initiation. Serine phosphorylation within the 14-3-3 binding sequence of the common beta-chain is also involved in GM-CSF, IL-3, and IL-5 receptor-specific functions (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nbeta common cytokine receptor; beta-GM-CSF receptor; betaGMR; CD131; CDw131; colony stimulating factor 2 receptor beta common subunit; colony stimulating factor 2 receptor subunit beta; colony stimulating factor 2 receptor, beta; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); colony-stimulating factor-2 receptor, beta, low-affinity; CSF2RB; Cytokine receptor common subunit beta; GM-CSF\/IL-3\/IL-5 receptor common beta subunit; GM-CSF\/IL-3\/IL-5 receptor common beta-chain; IL3RB; IL5RB; interleukin 3 receptor\/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity); SMDP5\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk Mi\nSENSITIVITY: Endogenous\nMW (kDa): 100\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799417770153,"sku":"3432S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-3432s","provider":"Iright","version":"1.0","type":"link"}