{"product_id":"cst-34808s","title":"CST,  34808S, IFNGR1 Antibody","description":"Polyclonal Antibody for studying IFNGR1. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, IFNGR1 Antibody (CST #34808) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIFNGR1 Antibody recognizes endogenous levels of total IFNGR1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human IFNGR1 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nIFN-γ plays key roles in both the innate and adaptive immune response. IFN-γ activates the cytotoxic activity of innate immune cells, such as macrophages and NK cells (1,2). IFN-γ production by NK cells and antigen presenting cells (APCs) promotes cell-mediated adaptive immunity by inducing IFN-γ production by T lymphocytes, increasing class I and class II MHC expression, and enhancing peptide antigen presentation (1). Due to differences in the degree of glycosylation, there are three forms of IFN-γ, with approximate molecular weights of 25, 20, and 15.5 kDa by SDS-PAGE (5). The anti-viral activity of IFN-γ is due to its induction of PKR and other regulatory proteins. Binding of IFN-γ to the IFNGR1\/IFNGR2 complex promotes dimerization of the receptor complexes to form the (IFNGR1\/IFNGR2) -IFN-γ dimer. Binding induces a conformational change in receptor intracellular domains and signaling involves Jak1, Jak2, and Stat1 (3). The critical role of IFN-γ in amplification of immune surveillance and function is supported by increased susceptibility to pathogen infection by IFN-γ or IFNGR knockout mice and in humans with inactivating mutations in or . IFN-γ also appears to have a role in atherosclerosis (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nantiviral protein, type 2; AVP, type 2; CD119; CD119 antigen; CDw119; FLJ45734; IFN GAMMA RECEPTOR 1; IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; IFNGR; IFNGR1; IMD27A; IMD27B; immune interferon receptor 1; INGR1; Interferon gamma receptor 1; Interferon gamma receptor alpha-chain; interferon-gamma receptor alpha chain\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 45-90\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799422390441,"sku":"34808S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-34808s","provider":"Iright","version":"1.0","type":"link"}