{"product_id":"cst-35127c","title":"CST,  35127C, PathScan® RP TMEM106B Sandwich ELISA Kit","description":"ELISA Kit for studying TMEM106B in the research area.\n\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: ELISA+\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nThe PathScan\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eBackground\u003c\/b\u003e\nTransmembrane protein 106B (TMEM106B) is a type II transmembrane protein with unknown function (1). was first identified as a major risk factor in genome-wide association studies in patients with frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder characterized by atrophy in the frontal and temporal lobes of the brain (2). Localization of TMEM106B in late endosomal\/lysosomal compartments suggests a role in regulating endo-lysosomal morphology and function (3). Endo-lysosomal dysfunction is likely a major cellular pathway that contributes to FTLD as other genetically linked FTLD genes, including , , and , converge on this cellular pathway (4). TMEM106B is sequentially processed through ectodomain shedding, followed by intramembrane proteolysis, with possible variability in the intramembrane cleavage site. Fragments consisting of residues 120-254 of TMEM106B have been shown to form amyloid filaments in human brains (5-7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ11273; HLD16; MGC33727; T106B; TMEM106B; TMEM106B protein; Transmembrane protein 106B\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk","brand":"CST","offers":[{"title":"Default Title","offer_id":46800594698409,"sku":"35127C","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-35127c","provider":"Iright","version":"1.0","type":"link"}