{"product_id":"cst-35269s","title":"CST,  35269S, FoxA1\/HNF3 alpha (E7E8W) Rabbit Monoclonal Antibody (Biotinylated)","description":"Monoclonal Antibody for studying FOXA1. Validated for Western Blotting. Highly specific and rigorously validated in-house, FoxA1\/HNF3 alpha (E7E8W) Rabbit Monoclonal Antibody (Biotinylated) (CST #35269) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 140 mM NaCl, 3 mM KCI, 10 mM sodium phosphate (pH 7.4) dibasic, 2 mM potassium phosphate monobasic, 2 mg\/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nFoxA1\/HNF3 alpha (E7E8W) Rabbit Monoclonal Antibody (Biotinylated) recognizes endogenous levels of total FoxA1\/HNF3α protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human FoxA1\/HNF3α protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nForkhead box protein A1 (FoxA1, HNF3α) is a transcription factor required for the development of endoderm-derived organs, such as liver, lung, and prostate (1). FoxA1 functions as a pioneer factor that is recruited primarily to the distant enhancers to change chromatin structure for transcription in a cell type-specific manner (2,3). The FoxA1 transcription factor is implicated in various diseases, playing a role in hormone-dependent disorders, such as breast and prostate cancers (4). The treatment of relapsing-remitting multiple sclerosis patients with IFN-β results in FoxA1-induced stimulation of a novel population of FoxA1(+) regulatory T cells, suggesting a possible immunosuppressive role for FoxA1 (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nforkhead box A1; Forkhead box protein A1; FOXA1; Hepatocyte nuclear factor 3-alpha; hepatocyte nuclear factor 3, alpha; HNF-3-alpha; HNF-3A; HNF3A; MGC33105; TCF-3A; TCF3A; Transcription factor 3A\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 50\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800384295081,"sku":"35269S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-35269s","provider":"Iright","version":"1.0","type":"link"}