{"product_id":"cst-35333s","title":"CST,  35333S, CDDO-Me","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nCDDO-Me is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 0.99 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles .\n\u003cb\u003eBackground\u003c\/b\u003e\nCDDO-Me (bardoxolone methyl) is a synthetic triterpenoid that induces apoptosis and differentiation in cancer cells, and exhibits strong antiproliferative and antiangiogenic activities (1). CDDO-Me activates nuclear factor-like 2 (NRF2) transcriptional activator, which regulates oxidative stress response gene expression through binding of antioxidant response element (ARE) promoter gene regions. CDDO-Me interacts with the NRF2 inhibitor INrf2 (also called KEAP1), resulting in the release of NRF2 from the proteasome pathway and translocation of NRF2 into the nucleus (2). Additionally, CDDO-Me binds IKKβ to block the targeting of NF-κB p65 to the nucleus and inhibits NF-κB activation and downstream pro-inflammatory signaling pathways (3). CDDO-Me has been studied as an anticancer and anti-inflammatory drug, with potential to treat patients with chronic kidney disease associated with diabetes (4). Low doses of CDDO-Me may exert therapeutic effects on cardiac function in models of chronic heart failure (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n12-dioxooleana-1,9(11)-dien-28-oic acid methyl ester; 2-Cyano-3; CDDO Methyl ester; NSC 713200; RTA 402","brand":"CST","offers":[{"title":"Default Title","offer_id":46800694509737,"sku":"35333S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-35333s","provider":"Iright","version":"1.0","type":"link"}