{"product_id":"cst-3553s","title":"CST,  3553S, Zyxin Antibody","description":"Polyclonal Antibody for studying zyxin. Validated for Western Blotting. Highly specific and rigorously validated in-house, Zyxin Antibody (CST #3553) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nZyxin Antibody recognizes endogenous levels of total zyxin protein.\nSpecies Reactivity: Human, Mouse, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Phe314 of human zyxin protein. Antibodies are purified using protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe zyxin family of proteins includes LIMD1, ajuba, trip6 and zyxin, each of which contains three LIM domains at the carboxy-terminus. Zyxin family members associate with the actin cytoskeleton and are components of both the cell-cell junction adhesive complex and the integrin-mediated adhesive complex. They shuttle in and out of the nucleus where they may function in transcriptional activation (1). Zyxin is involved in the regulation of mechanical force-induced actin polymerization at focal adhesions (2), and in regulation of adhesion and migration, possibly through recruitment of Ena\/VASP proteins to focal adhesions (3). Zyxin interacts with and may regulate the function of the tumor suppressor myopodin, which inhibits tumor growth and metastasis (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nESP-2; HED-2; ZYX; Zyxin; Zyxin-2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M Mk\nSENSITIVITY: Endogenous\nMW (kDa): 78\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799429402793,"sku":"3553S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-3553s","provider":"Iright","version":"1.0","type":"link"}