{"product_id":"cst-35909t","title":"CST,  35909T, IFI35 (E3A8S) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Ifi35. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, IFI35 (E3A8S) Rabbit Monoclonal Antibody (CST #35909) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIFI35 (E3A8S) Rabbit Monoclonal Antibody recognizes endogenous levels of total IFI35 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val250 of human IFI35 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nInterferon-induced 35 kDa protein (IFI35) is a leucine zipper-containing protein that is upregulated in response to type I and type II interferons (1,2). Research studies have demonstrated that intracellular pools of IFI35, in complex with NMI, negatively regulate innate immune antiviral signaling by blunting type I interferon production (3,4). Extracellularly, IFI35 has been shown to modulate the innate immune response by functioning as a proinflammatory damage-associated molecular pattern (DAMP) upon release by activated macrophages (5,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ21753; Ifi-35; IFI35; IFP 35; IFP35; IN35; interferon induced protein 35; Interferon-induced 35 kDa protein; interferon-induced protein 35\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 32\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799434449065,"sku":"35909T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-35909t","provider":"Iright","version":"1.0","type":"link"}