{"product_id":"cst-36057t","title":"CST,  36057T, SNAT1\/SLC38A1 (D9L2P) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SNAT1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, SNAT1\/SLC38A1 (D9L2P) Rabbit Monoclonal Antibody (CST #36057) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSNAT1\/SLC38A1 (D9L2P) Rabbit Monoclonal Antibody recognizes endogenous levels of total SNAT1\/SLC38A1 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly37 of human SNAT1\/SLC38A1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSNAT1\/SLC38A1 belongs to the system A transporters that mediate Na -dependent transport of short-chain neutral amino acids such as alanine, serine, and glutamine. SNAT1\/SLC38A1 mediates the uptake of glutamine in neurons and plays a crucial role in glutamate-glutamine cycle. Steep concentration gradients across the plasma membrane are achieved by coupling of the electrochemical sodium gradient to amino acid transport. This allows a unidirectional mode of transport for SNAT1\/SLC38A1. Upregulation of SNAT1\/SLC38A1 by neurotrophic factors is key to dendritic growth and branching of cortical neurons. High expression of SNAT1\/SLC38A1 is found in cerebral cortex primarily in neurons and to a lesser extent in astrocytes (1-4). Elevated SNAT1\/SLC38A1 expression is prominent in human solid tumors including gliomas, hepatocellular carcinomas and human breast cancer (5-8). Research studies show that an aberrant SNAT1\/SLC38A1 expression profile correlates with solid tumor recurrence and poor prognosis in patients with cholangiocarcinoma (9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAmino acid transporter A1; amino acid transporter system A1; ATA1; N-system amino acid transporter 2; NAT2; S38A1; SAT1; SLC38A1; SNAT1; Sodium-coupled neutral amino acid symporter 1; Sodium-coupled neutral amino acid transporter 1; Solute carrier family 38 member 1; solute carrier family 38, member 1; System A amino acid transporter 1; System N amino acid transporter 1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 50-70\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799440478377,"sku":"36057T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-36057t","provider":"Iright","version":"1.0","type":"link"}