{"product_id":"cst-36342t","title":"CST,  36342T, RASA2 (F2O1I) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying RASA2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, RASA2 (F2O1I) Rabbit Monoclonal Antibody (CST #36342) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nRASA2 (F2O1I) Rabbit Monoclonal Antibody recognizes endogenous levels of total RASA2 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val200 of human RASA2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nRas GTPase-activating protein 2 (RASA2) belongs to the GAP1 subfamily of Ras-GAPs and serves as one of the major Ras-specific GAPs. RASA2 functions to inhibit Ras by facilitating activation of its intrinsic GTPase activity. Similar to other members of the GAP1 subfamily, RASA2 contains calcium-binding C2 domains and a phospholipid binding PH domain (1). Research studies have pointed to RASA2 as an inhibitor of Ras signaling in the context of human cancer, including melanoma (2). More recently, RASA2 has been identified as a negative regulator of T cell effector function through its function as a Ras-specific GAP (3,4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nGAP1M; GTPase-activating protein 1m; GTPase-activating protein of RAS; Ras GTPase-activating protein 2; RAS p21 protein activator 2; RASA2; RASGAP\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799443361961,"sku":"36342T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-36342t","provider":"Iright","version":"1.0","type":"link"}