{"product_id":"cst-36418s","title":"CST,  36418S, Langerin (F8L8I) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CD207. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, Langerin (F8L8I) Rabbit Monoclonal Antibody (CST #36418) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLangerin (F8L8I) Rabbit Monoclonal Antibody recognizes endogenous levels of total Langerin protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val324 of human Langerin protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nLangerin (CD207) is a C-type lectin receptor whose expression is restricted mainly to dendritic cells in the skin, including Langerhans cells in the epidermis and langerin \/CD103 dermal dendritic cells (1-4). Langerin is found on the cell surface and within rod-shaped organelles called Birbeck granules, and its expression is required for the formation of Birbeck granules (1,5). Langerin recognizes carbohydrate motifs on the surface of pathogens, resulting in endocytosis of the pathogen into Birbeck granules, degradation of the pathogen, and antigen presentation to T cells (6-8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC-type lectin domain family 4 member K; C-type lectin domain family 4, member K; CD207; CD207 antigen, langerin; CD207 molecule; CD207 molecule, langerin; CLC4K; CLEC4K; Langerhans cell specific c-type lectin; Langerin\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 40-50\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799443919017,"sku":"36418S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-36418s","provider":"Iright","version":"1.0","type":"link"}