{"product_id":"cst-36809t","title":"CST,  36809T, Caspase-14 (D3J3D) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Casp14. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Caspase-14 (D3J3D) Rabbit Monoclonal Antibody (CST #36809) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCaspase-14 (D3J3D) Rabbit Monoclonal Antibody recognizes endogenous levels of total caspase-14 protein. Endogenous levels of the p20 activated subunit have not been detected.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala71 of human caspase-14 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCaspases are a family of cysteine proteases that play an essential role in carrying out apoptosis. Caspase-14, also named MICE, is a unique member of the caspase family with restricted expression; it is found in embryonic tissues and adult skin (1,2). Caspase-14 is weakly processed into p18 and p11 subunits by caspase-8 (2). Caspase-14 may not play a role in apoptosis (2), but instead may regulate keratinocyte differentiation (3). Expression of caspase-14 may protect from psoriasis (4,5) and irradiation damage (6). Caspase-14 may also be responsible for proteolytic processing of filaggrin during terminal differentiation of keratinocytes (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\napoptosis-related cysteine protease; ARCI12; CASP-14; CASP14; caspase 14; caspase 14, apoptosis-related cysteine peptidase; caspase 14, apoptosis-related cysteine protease; Caspase-14; Caspase-14 subunit p10; Caspase-14 subunit p10, mature form; Caspase-14 subunit p17, mature form; Caspase-14 subunit p19; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form; CASPE; MGC119078; MGC119079\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 28-30\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799447556265,"sku":"36809T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-36809t","provider":"Iright","version":"1.0","type":"link"}