{"product_id":"cst-36845s","title":"CST,  36845S, OASL (E7W1R) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying OASL. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, OASL (E7W1R) Rabbit Monoclonal Antibody (CST #36845) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nOASL (E7W1R) Rabbit Monoclonal Antibody recognizes endogenous levels of total OASL protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys504 of human OASL protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe 2'-5'-oligoadenylate synthetase (OAS) family of interferon-induced proteins plays an important role in cellular innate immune response (1-4). When activated by double-stranded RNA, these proteins polymerize ATP into 2′-5′-linked oligomers (2,3,5). These 2'-5'-linked oligoadenylates bind to the ribonuclease RNase L, degrading viral and cellular RNA (2,3,5). In humans, the OAS family of proteins includes OAS1, OAS2, OAS3, and OASL (1-3). OASL differs from the other OAS family members in that it lacks 2'-5' oligoadenylate synthase activity, but can bind double-stranded RNA (6). Recent studies have shown that OASL shows antiviral activity via an alternative antiviral pathway independent of RNase L (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n2'-5'-OAS-related protein; 2'-5'-OAS-RP; 2'-5'-oligoadenylate synthase-like protein; 2'-5'-oligoadenylate synthetase like; 2'-5'-oligoadenylate synthetase-like; 59 kDa 2'-5'-oligoadenylate synthase-like protein; 59 kDa 2'-5'-oligoadenylate synthetase-like protein; OASL; OASL1; OASLd; p59 OASL; p59-OASL; p59OASL; Thyroid receptor-interacting protein 14; TR-interacting protein 14; TRIP-14; TRIP14\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 52\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799447818409,"sku":"36845S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-36845s","provider":"Iright","version":"1.0","type":"link"}