{"product_id":"cst-36940s","title":"CST,  36940S, Human IL-3 Recombinant Protein","description":"Growth Factors and Cytokines for studying IL3 in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nHuman IL-3 Recombinant Protein is supplied as a lyophilized material that is very stable at -20ºC. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4ºC and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant human Interleukin-3 was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nInterleukin-3 (IL-3) is produced by T cells, mast cells, and eosinophils (1). Target cells include hematopoietic progenitors, neutrophils, macrophages, mast cells, eosinophils, lymphoid, and erythroid cells (1). The IL-3 receptor is a heterodimer of the IL-3 specific α-chain and the common β-chain, βc, which is also used by GM-CSF and IL-5. (1). Binding of IL-3 can also involve substitution of the βc by a βIL-3-chain that appears to be specific for IL-3 (1,2). Binding of IL-3 to its cognate receptor(s) induces activation of Jak2, phosphorylation of multiple Stats (1,3,5,6), and the PI3K\/Akt pathway (1). IL-3 may play an important role in the development of airway inflammation associated with asthma (3-5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nIL-3; IL3; Interleukin-3; Mast Cell Growth","brand":"CST","offers":[{"title":"Default Title","offer_id":46800713220265,"sku":"36940S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-36940s","provider":"Iright","version":"1.0","type":"link"}