{"product_id":"cst-36977s","title":"CST,  36977S, SLAMF6\/CD352 (E8K9W) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SLAMF6. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, SLAMF6\/CD352 (E8K9W) Rabbit Monoclonal Antibody (CST #36977) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSLAMF6\/CD352 (E8K9W) Rabbit Monoclonal Antibody recognizes endogenous levels of total SLAMF6\/CD352 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domain of human SLAMF6\/CD352 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSLAMF6 (CD352\/NTB-A) is a type-I transmembrane glycoprotein belonging to the signaling lymphocytic activation molecule (SLAM) family of immunomodulatory receptors. Like other members of the SLAM receptor family, SLAMF6 contains Ig-like domains within its extracellular region and conserved tyrosine-based signaling motifs within its intracellular domain that, when phosphorylated, bind to the SAP and EAT-2 signaling adaptors (1). SLAMF6 is expressed on the surface of multiple types of immune cells, such as those of the B, T, and NK lineages. Its activation is triggered by homotypic interactions involving its extracellular domain (1-3). Indeed, research studies have shown that in T cells, SLAMF6 engagement facilitates activation and cytokine production (4). Similarly, homotypic ligand-mediated engagement of SLAMF6 on NK cells activates signaling cascades that drive proliferation, cytotoxicity, and cytokine production (1,5-7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nActivating NK receptor; CD352; KALI; KALIb; Ly108; MGC104953; natural killer-, T- and B-cell antigen; NK-T-B-antigen; NTB-A; NTBA; NTBA receptor; SF2000; SLAF6; SLAM family member 6; SLAMF6\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 60\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799449391273,"sku":"36977S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-36977s","provider":"Iright","version":"1.0","type":"link"}