{"product_id":"cst-37041t","title":"CST,  37041T, AceCS2\/ACSS1 (E6T5E) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ACSS1. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, AceCS2\/ACSS1 (E6T5E) Rabbit Monoclonal Antibody (CST #37041) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nAceCS2\/ACSS1 (E6T5E) Rabbit Monoclonal Antibody recognizes endogenous levels of total AceCS2\/ACSS1 protein. This antibody does not cross-react with AceCS1\/ACSS2 protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly370 of human AceCS2\/ACSS1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMitochondrial acetyl-CoA synthetase 2 (AceCS2), also known as acyl-CoA synthetase short-chain family member 1 (ACSS1), catalyzes acetyl-CoA biosynthesis from acetate and CoA. Studies show that acetate levels go up dramatically at sites of infection and inflammation, leading to the decrease of acetate assimilating enzymes AceCS2\/ACSS1 and AceCS1\/ACSS2 levels in memory CD8 T cells. Acetate not metabolized by these enzymes instead stimulates glutaminase activity in memory CD8 T cells, enhancing glutaminolysis, mitochondrial respiration, and cell survival (1). In addition, AceCS2\/ACSS1 is highly expressed in one of the hepatocellular carcinoma (HCC) subtypes (2).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nACAS2L; ACECS1; AceCS2; AceCS2L; Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; acetyl-Coenzyme A synthetase 2 (AMP forming)-like; Acetyl-coenzyme A synthetase 2-like, mitochondrial; ACS2L; ACSS1; acyl-CoA synthetase short chain family member 1; Acyl-CoA synthetase short-chain family member 1; FLJ45659; KIAA1846; MGC33843; Propionate--CoA ligase\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 75\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799449882793,"sku":"37041T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-37041t","provider":"Iright","version":"1.0","type":"link"}