{"product_id":"cst-37095t","title":"CST,  37095T, PRPF4 (F9Z1U) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PRPF4. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PRPF4 (F9Z1U) Rabbit Monoclonal Antibody (CST #37095) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPRPF4 (F9Z1U) Rabbit Monoclonal Antibody recognizes endogenous levels of total PRPF4 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala278 of human PRPF4 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPRPF4 is a U4\/U6 snRNP-associated WD repeat-containing protein that is a critical regulator of the splicing process (1-3). PRPF4, PRPF3, and PPIH form a stable complex essential for proper formation and function of the U4\/U6.U5 tri-snRNP (3,4). PRPF4 associates with kinetochores and can affect mitosis checkpoint control through MPS1, MAD1, and MAD2 (5). PRPF4 also has been shown to play a role in pluripotency and stem cell differentiation (6). Mutations in cause autosomal dominant retinitis pigmentosa (7,8). Furthermore, knockdown of PRPF4 has been shown to reduce colony formation and cell growth in breast cancer cells (9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nhPrp4; HPRP4P; pre-mRNA processing factor 4; PRP4; PRP4 homolog; PRP4 pre-mRNA processing factor 4 homolog; PRP4 pre-mRNA processing factor 4 homolog (yeast); PRP4\/STK\/WD splicing factor; Prp4p; PRPF4; RP70; SNRNP60; U4\/U6 small nuclear ribonucleoprotein Prp4; U4\/U6 snRNP 60 kDa protein; WD splicing factor Prp4\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 60\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799450439849,"sku":"37095T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-37095t","provider":"Iright","version":"1.0","type":"link"}