{"product_id":"cst-3722s","title":"CST,  3722S, Pin1 Antibody","description":"Polyclonal Antibody for studying Pin1. Validated for Western Blotting. Highly specific and rigorously validated in-house, Pin1 Antibody (CST #3722) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPin1 Antibody detects endogenous levels of total Pin1 protein. This antibody does not cross-react with other proteins.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy-terminal residues of human Pin1. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nPin1, a member of the parvulin family of peptidyl-prolyl isomerases (PPIase), has been implicated in the G2\/M transition of the mammalian cell cycle (1-6). Pin1 is a small (18 kDa) protein with two distinct functional domains: an amino-terminal WW domain and a carboxy-terminal PPlase domain. Pin1 interacts with several mitotic phosphoproteins, including Plk1, cdc25C and cdc27, and is thought to act as a phosphorylation-dependent PPlase for these target molecules (7-9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDOD; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1; peptidyl-prolyl cis\/trans isomerase, NIMA-interacting; peptidylprolyl cis\/trans isomerase, NIMA-interacting 1; PIN1; PPIase Pin1; prolyl isomerase; protein (peptidyl-prolyl cis\/trans isomerase) NIMA-interacting 1; protein (peptidylprolyl cis\/trans isomerase) NIMA-interacting 1; protein interacting with never in mitosis A1; Rotamase Pin1; UBL5\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 18\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799451390121,"sku":"3722S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-3722s","provider":"Iright","version":"1.0","type":"link"}