{"product_id":"cst-3771l","title":"CST,  3771L, Phospho-Jak2 (Tyr1007\/1008) Antibody","description":"Polyclonal Antibody for studying Jak2 (Tyr1007\/Tyr1008) phosphate. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-Jak2 (Tyr1007\/1008) Antibody (CST #3771) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPhospho-Jak2 (Tyr1007\/1008) Antibody detects endogenous levels of Jak2 only when phosphorylated at Tyr1007\/1008. This antibody may cross-react with phospho-Jak1 and phospho-Tyk2.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1007\/1008 of human Jak2 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nMembers of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains. The tyrosine residues 1007\/1008 of Jak2 in the putative activation loop are the homologous tyrosine residues 1054\/1055 in Tyk2, which are important in the regulation of Tyk2 kinase activity (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nJAK-2; JAK2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK10; Tyrosine-protein kinase JAK2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 125\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799456600233,"sku":"3771L","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-3771l","provider":"Iright","version":"1.0","type":"link"}