{"product_id":"cst-37936s","title":"CST,  37936S, NVP-DKY709","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nNVP-DKY709 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.20 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles .\n\u003cb\u003eBackground\u003c\/b\u003e\nNVP-DKY709 is a selective cereblon (CRBN) glue degrader that targets the IKZF2 Helios (Ikaros family zinc finger 2, IKZF2) protein for degradation. Helios is a member of the Ikaros transcription factor family that suppresses immune system response to pathogens by promoting regulatory T cell (Treg) activity (1). Treg cells are responsible for suppressing excessive immune responses and exhausting tumor-specific effector T (Teff) cell actions (1), inhibiting immune responses to cancer cells (2). Glue degraders on the market and in trial phases degrade other members of the Ikaros transcription factor family, including IKZF1 \u0026amp; IKZF3, which is suboptimal due to potential increase in immunosuppressive actions (1); NVP-DKY709 has been found only to degrade IKZF2, leaving IKZF1\/3 untouched (3), and has a DC of 4 nM in cellular assays (1).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800694673577,"sku":"37936S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-37936s","provider":"Iright","version":"1.0","type":"link"}