{"product_id":"cst-3801t","title":"CST,  3801T, MMP-7 (D4H5) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MMP7 mouse. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, MMP-7 (D4H5) Rabbit Monoclonal Antibody (CST #3801) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 50116 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMMP-7 (D4H5) Rabbit Monoclonal Antibody detects endogenous levels of total MMP-7 protein.\nSpecies Reactivity: Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile264 of mouse MMP-7 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors, and adhesion molecules (1). Among the family members, MMP-2, MMP-3, MMP-7, and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis, and apoptosis (2-4). Research studies have shown that MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full-length protein (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nMAT; Matrilysin; matrilysin, uterine; Matrin; matrix metallopeptidase 7; matrix metalloproteinase 7; Matrix metalloproteinase-7; MMP-7; Mmp7; Pump-1 protease; Uterine metalloproteinase\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M R\nSENSITIVITY: Endogenous\nMW (kDa): 28, 20-22\nSource\/Isotype: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46800092430505,"sku":"3801T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-3801t","provider":"Iright","version":"1.0","type":"link"}