{"product_id":"cst-38328t","title":"CST,  38328T, ARID4A\/RbBP1 (E2T6V) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying RbBP1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, ARID4A\/RbBP1 (E2T6V) Rabbit Monoclonal Antibody (CST #38328) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nARID4A\/RbBP1 (E2T6V) Rabbit Monoclonal Antibody recognizes endogenous levels of total ARID4A\/RbBP1 protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly813 of human ARID4A\/RbBP1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nARID4A\/RbBP1 was originally identified as an RB binding protein, which could repress E2F-mediated transcription through the recruitment of the mSIN3A complex (1-3). Like other AT-rich interacting domain (ARID) containing proteins, ARID4A\/RbBP1 functions as a tumor suppressor, and is frequently mutated in colorectal cancer (4-6). ARID4A\/RbBP1 and ARID4B\/RbBP1L1 are mainly expressed in Sertoli cells in the testes, where they form a complex and serve as coactivators for androgen receptors to regulate spermatogenesis (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nARI4A; ARID domain-containing protein 4A; ARID4A; AT rich interactive domain 4A (RBP1-like); AT-rich interaction domain 4A; AT-rich interactive domain-containing protein 4A; RBBP-1; RBBP1; RBP-1; RBP1; retinoblastoma binding protein 1; Retinoblastoma-binding protein 1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 205\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799461712041,"sku":"38328T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-38328t","provider":"Iright","version":"1.0","type":"link"}