{"product_id":"cst-38341s","title":"CST,  38341S, CD4 (RM4-5) Rat Monoclonal Antibody (PE-Cy7® Conjugate)","description":"Monoclonal Antibody for studying CD4 mouse. Validated for Flow Cytometry (Fixed\/Permeabilized),Flow Cytometry (Live). Highly specific and rigorously validated in-house, CD4 (RM4-5) Rat Monoclonal Antibody (PE-Cy7\u003csup\u003e®\u003c\/sup\u003e Conjugate) (CST #38341) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFor optimal flow cytometry results, we recommend 0.06 μg of antibody per test.\nFlow Cytometry (Fixed\/Permeabilized): 1:300\nFlow Cytometry (Live): 1:300\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM NaH 2 PO 4 , 150 mM NaCl, 0.09% NaN 3 , 0.1% gelatin, pH 7.2. This product is stable for 6 months when stored at 4ºC. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Flow Cytometry (Fixed\/Permeabilized), Flow Cytometry (Live)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD4 (RM4-5) Rat Monoclonal Antibody (PE-Cy7\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nThis monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.\n\u003cb\u003eBackground\u003c\/b\u003e\nCluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part, and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen-Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR-antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and recruits the tyrosine kinase Lck, which is essential for T cell activation (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCd4; CD4 antigen; L3T; L3T4; Ly-; Ly-4; OTTMUSP00000027399; T-cell differentiation antigen L3T4; T-cell surface antigen T4\/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4\/Leu-3) (T-cell differentiation antigen L3T4)\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nSource\/Isotype: Rat IgG2a kappa","brand":"CST","offers":[{"title":"Default Title","offer_id":46800390029481,"sku":"38341S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-38341s","provider":"Iright","version":"1.0","type":"link"}