{"product_id":"cst-38410t","title":"CST,  38410T, SNF2H (D4W6N) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SNF2H. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, SNF2H (D4W6N) Rabbit Monoclonal Antibody (CST #38410) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSNF2H (D4W6N) Rabbit Monoclonal Antibody recognizes endogenous levels of total SNF2H protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala65 of human SNF2H protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSucrose nonfermenting 2 homolog (SNF2H, SMARCA5) is one of two orthologs of the ISWI (imitation switch) ATPases encoded by the mammalian genome (1). SNF2H is part of the SNF2 family of chromatin remodeling factors that use ATP hydrolysis to catalyze biochemical reactions in several mammalian chromatin-remodeling complexes, including ACF1, RSF1, CHRAC, NoRC, WSTF, and WCRF180 (2). Research studies show that SNF2H is crucial for chromatin organization, DNA damage response, and differentiation (1-7). The SNF2H helicase facilitates DNA damage repair by actively moving nucleosomes for DNA damage response (DDR) proteins to effectively associate with damaged regions (3). Additional studies show that repair of double stranded breaks (DSBs) significantly decreases in the absence of SNF2H (3), and these cells become highly sensitive to DNA damage caused by x-rays and chemical treatments inducing DSBs (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nhISWI; hSNF2H; ISWI; SMARCA5; SMCA5; SNF2H; Sucrose nonfermenting protein 2 homolog; sucrose nonfermenting-like 5; SWI\/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5; SWI\/SNF-related matrix-associated actin-dependent regulator of chromatin A5; SWI\/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; WCRF135\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 125\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799462367401,"sku":"38410T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-38410t","provider":"Iright","version":"1.0","type":"link"}