{"product_id":"cst-38521s","title":"CST,  38521S, Myelin Basic Protein (D8X4Q) Mouse Chimeric Monoclonal Antibody","description":"Monoclonal Antibody for studying MBP. Validated for Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, Myelin Basic Protein (D8X4Q) Mouse Chimeric Monoclonal Antibody (CST #38521) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nImmunofluorescence (Frozen): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Immunofluorescence (Frozen)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMyelin Basic Protein (D8X4Q) Mouse Chimeric Monoclonal Antibody recognizes endogenous levels of total myelin basic protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nThis recombinant chimeric antibody is engineered from Myelin Basic Protein (D8X4Q) XP  Rabbit mAb #78896 according to animal-free protocols. The chimeric antibody retains its antigen-binding Fab regions from the original rabbit monoclonal antibody but contains a mouse-derived Fc domain. When multiplexing, Fc-directed rabbit secondaries are required to detect rabbit-host primary antibodies.  The parent antibody, Myelin Basic Protein (D8X4Q) XP  Rabbit mAb #78896, is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala185 of human myelin basic protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMyelin basic protein (MBP) is an abundant central nervous system (CNS) myelin membrane protein that plays an important role in nerve myelination. Myelin sheaths are multi-layered membranes derived from oligodendrocytes that increase the conduction velocity of axonal impulses. MBP helps to adhere the cytoplasmic leaflets of adjacent oligodendrocyte membranes to one another. Several splice variants of MBP are expressed in cells and the protein is modified following translation (i.e., phosphorylation, methylation), which suggests additional membrane adhesion functions (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nGolli-MBP; MBP; MGC99675; Myelin A1 protein; Myelin basic protein; Myelin membrane encephalitogenic protein; proline-rich proteoglycan 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nSource\/Isotype: Mouse chimeric IgG2a","brand":"CST","offers":[{"title":"Default Title","offer_id":46800294084777,"sku":"38521S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-38521s","provider":"Iright","version":"1.0","type":"link"}