{"product_id":"cst-3863s","title":"CST,  3863S, MOB1 Antibody","description":"Polyclonal Antibody for studying MOB1A\/MOB1B. Validated for Western Blotting. Highly specific and rigorously validated in-house, MOB1 Antibody (CST #3863) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMOB1 Antibody detects endogenous levels of total MOB1 protein (MOB1α and MOB1β).\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro15 of human MOB1. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nMOB1 was first identified in yeast as a protein that binds to Mps with essential roles in the completion of mitosis and the maintenance of ploidy (1). Its and mammalian homologs, Mats and MOB1, respectively, are involved in the Hippo signaling tumor suppressor pathway, which plays a critical role in organ size regulation and which has been implicated in cancer development (2-5). There are two MOB1 proteins in humans, MOB1A and MOB1B, that are encoded by two different genes but which have greater than 95% amino acid sequence identity (6). Both forms bind to members of the nuclear Dbf2-related (NDR) kinases, such as LATS1\/2 and NDR1\/2, thereby stimulating kinase activity (7-9). This binding is promoted by the phosphorylation of MOB1 at several threonine residues (e.g., Thr12, Thr35) by MST1 and\/or MST2 (5,10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC2orf6; FLJ10788; FLJ11595; MATS1; MATS2; MGC33910; MOB kinase activator 1A; MOB kinase activator 1B; MOB1; Mob1 alpha; Mob1 homolog 1A; Mob1 homolog 1B; MOB1 Mps One Binder homolog A; MOB1 Mps One Binder homolog B; MOB1, Mps One Binder kinase activator-like 1A; MOB1, Mps One Binder kinase activator-like 1A (yeast); MOB1, Mps One Binder kinase activator-like 1B; MOB1, Mps One Binder kinase activator-like 1B (yeast); Mob1A; Mob1B; MOB4A; MOB4B; MOBK1B; MOBKL1A; MOBKL1B; MOL1A; MOL1B; Mps one binder kinase activator-like 1A; Mps one binder kinase activator-like 1B; Protein Mob4A; Protein Mob4B\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 24\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799464169641,"sku":"3863S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-3863s","provider":"Iright","version":"1.0","type":"link"}