{"product_id":"cst-39065s","title":"CST,  39065S, Granzyme B (D2H2F) Rabbit Monoclonal Antibody (InTraSeq™ 3' Conjugate 3110)","description":"Monoclonal Antibody for studying Granzyme B. Validated for Single Cell Analysis - InTraSeq™ 3'. Highly specific and rigorously validated in-house, Granzyme B (D2H2F) Rabbit Monoclonal Antibody (InTraSeq\u003csup\u003e™\u003c\/sup\u003e 3' Conjugate 3110) (CST #39065) is ready to ship.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), 2 mM EDTA, 0.05% Triton X-100, 2 mg\/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Single Cell Analysis - InTraSeq™ 3'\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nGranzyme B (D2H2F) Rabbit mAb (InTraSeq™ 3' Conjugate 3110) recognizes endogenous levels of total Granzyme B protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to human Granzyme B protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nGranzymes are a family of serine proteases expressed by cytotoxic T lymphocytes and natural killer (NK) cells and are key components of immune responses to pathogens and transformed cells (1). Granzymes are synthesized as zymogens and are processed into mature enzymes by cleavage of a leader sequence. They are released by exocytosis in lysosome-like granules containing perforin, a membrane pore-forming protein. Granzyme B has the strongest apoptotic activity of all the granzymes as a result of its caspase-like ability to cleave substrates at aspartic acid residues thereby activating procaspases directly and cleaving downstream caspase substrates (2,3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC11; Cathepsin G-like 1; CCPI; CGL-1; CGL1; CSP-B; CSPB; CTLA-1; CTLA1; CTSGL1; cytotoxic serine protease B; Cytotoxic T-lymphocyte proteinase 2; fragmentin 2; Fragmentin-2; GRAB; Granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); Granzyme-2; GRB; GZMB; HLP; Human lymphocyte protein; Lymphocyte protease; SECT; T-cell serine protease 1-3E\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800777052329,"sku":"39065S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-39065s","provider":"Iright","version":"1.0","type":"link"}