{"product_id":"cst-39070s","title":"CST,  39070S, LARG (E4I3L) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying LARG. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, LARG (E4I3L) Rabbit Monoclonal Antibody (CST #39070) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLARG (E4I3L) Rabbit Monoclonal Antibody recognizes endogenous levels of total LARG protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human LARG protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe leukemia-associated Rho guanine nucleotide exchange factor (LARG, also known as ARHGEF12) was originally identified as a novel fusion partner of the mixed-lineage leukemia protein in an acute myeloid leukemia patient. LARG activates RhoA and RhoC but not Rac1 or Cdc42. (1,2). It has been shown to play a role in glioblastoma cell invasion and resistance (2). Furthermore, LARG is associated with certain forms of synaptic plasticity, where, as a binding partner of GluD1, it plays a role in inhibitory synapse formation (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nARHGC; ARHGEF12; DKFZp686O2372; KIAA0382; LARG; leukemia-associated rho guanine nucleotide exchange factor; Leukemia-associated RhoGEF; PRO2792; Rho guanine nucleotide exchange factor (GEF) 12; Rho guanine nucleotide exchange factor 12\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 220\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799468036265,"sku":"39070S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-39070s","provider":"Iright","version":"1.0","type":"link"}