{"product_id":"cst-39127s","title":"CST,  39127S, Mouse Interferon-gamma (mIFN-gamma) Recombinant Protein","description":"Growth Factors and Cytokines for studying IFN-gamma mouse in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWorking concentration of recombinant mIFN-γ generally ranges from 0.1-10 ng\/ml.\n\u003cb\u003eStorage\u003c\/b\u003e\nRecombinant mouse IFN-γ is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/ml which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant mouse IFN-γ was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nIFN-γ plays key roles in both the innate and adaptive immune response. IFN-γ activates the cytotoxic activity of innate immune cells such as macrophages and NK cells (1,2). IFN-γ production by NK cells and antigen-presenting cells (APCs) promotes cell-mediated adaptive immunity by inducing IFN-γ production by T lymphocytes, increased class I and class II MHC expression, and enhancing peptide antigen presentation (1). The anti-viral activity of IFN-γ is due to its induction of PKR and other regulatory proteins. Binding of IFN-γ to the IFNGR1\/IFNGR2 complex promotes dimerization of the receptor complexes. Binding induces a conformational change in receptor intracellular domains and signaling involves Jak1, Jak2, and Stat1 (3). The critical role of IFN-γ in amplification of immune surveillance and function is supported by increased susceptibility to pathogen infection by IFN-γ or IFNGR knockout mice, and in humans with inactivating mutations in IFNGR1 or IFNGR2. IFN-γ also appears to have a role in atherosclerosis (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nIFN; IFN gamma; IFN-gamma; ifng; interferon","brand":"CST","offers":[{"title":"Default Title","offer_id":46800713416873,"sku":"39127S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-39127s","provider":"Iright","version":"1.0","type":"link"}