{"product_id":"cst-39138s","title":"CST,  39138S, SNX5 (E4Q2X) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SNX5. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, SNX5 (E4Q2X) Rabbit Monoclonal Antibody (CST #39138) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSNX5 (E4Q2X) Rabbit Monoclonal Antibody recognizes endogenous levels of total SNX5 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu216 of human SNX5 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSorting nexins (SNXs) are a family of cytoplasmic proteins characterized by the presence of a phosphatidylinositol 3-phosphate (PI3P) binding phox (PX) domain. This binding occurs mainly in the early endosome and allows for trafficking of the bound protein to either a degradative or recycling pathway (1). The sorting nexin family member SNX5 was identified in binding studies with Fanconi anemia complementation group A (FANCA) protein (2). In addition to the PX domain, STX5 has a Bin\/Amphiphysin\/Rvs (BAR) domain that can sense membrane curvature and induce membrane tubulation (3). Aberrant expression of SNX5 can contribute to tumorigenesis, invasion, and metastasis of several human cancers (4-7). Elevated expression of SNX5 has been reported in Parkinson's disease, where it may have a role in promoting ferroptosis (8). Studies have found that SNX5 has an essential role in macropinocytosis (9). In addition, SNX5 is part of a complex involved in recognizing membrane curvature on autolysosomes and regulating recycling of autophagosomal components (10). In a genome-wide siRNA, SNX5 was found to be an essential protein involved in virus-mediated autophagy and immunity (11).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ10931; SNX5; sorting nexin 5; Sorting nexin-5\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 47\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799468527785,"sku":"39138S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-39138s","provider":"Iright","version":"1.0","type":"link"}