{"product_id":"cst-39901s","title":"CST,  39901S, IL-17A (D1X7L) Rabbit Monoclonal Antibody (PE Conjugate)","description":"Monoclonal Antibody for studying IL17A mouse. Validated for Flow Cytometry (Fixed\/Permeabilized). Highly specific and rigorously validated in-house, IL-17A (D1X7L) Rabbit Monoclonal Antibody (PE Conjugate) (CST #39901) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFlow Cytometry (Fixed\/Permeabilized): 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg\/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Flow Cytometry (Fixed\/Permeabilized)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIL-17A (D1X7L) Rabbit Monoclonal Antibody (PE Conjugate) recognizes endogenous levels of total mouse IL-17A protein.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val49 of mouse IL-17A protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe IL-17 family of cytokines consists of IL-17A-F, and their receptors include IL-17RA-RE (1). IL-17 cytokines are produced by a variety of cell types including the Th17 subset of CD4+ T cells, as well as subsets of γδ T cells, NK cells, and NKT cells (2). IL-17A and IL-17F, the most well-studied of the IL-17 cytokines, contribute to fungal and bacterial immunity by inducing expression of proinflammatory cytokines, chemokines, and antimicrobial peptides (2). In addition, IL-17A contributes to the pathogenesis of several autoimmune diseases (3). IL-17E promotes Th2 cell responses (4). The roles of IL-17B, IL-17C, and IL-17D are less clear, however these family members also appear to have the capacity to induce proinflammatory cytokines (1,5,6). IL-17 receptors have an extracellular domain, a transmembrane domain, and a SEFIR domain. They are believed to signal as homodimers, heterodimers, or multimers through their SEFIR domain by recruiting the SEFIR domain-containing adaptor Act1 (7). Unlike most cytokines that signal through Jak\/STAT pathways, IL-17 signaling results in NF-κB activation (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCtl; Ctla; CTLA-8; Ctla8; Cytotoxic T-lymphocyte-associated antigen 8; IL-; IL-17; IL-17A; Il17; Il17a; interleukin 17A; Interleukin-17A\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800393371817,"sku":"39901S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-39901s","provider":"Iright","version":"1.0","type":"link"}