{"product_id":"cst-40036s","title":"CST,  40036S, ENPP1 (E4I2P) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ENPP1 mouse. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, ENPP1 (E4I2P) Rabbit Monoclonal Antibody (CST #40036) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nENPP1 (E4I2P) Rabbit Monoclonal Antibody recognizes endogenous levels of total ENPP1 protein.\nSpecies Reactivity: Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu281 of mouse ENPP1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nEctonucleotide pyrophosphatase-phosphodiesterase 1 (ENPP1) is a single-pass, type II transmembrane protein primarily involved in ATP hydrolysis at the plasma membrane. Targeting of ENPP1 to the basolateral cell surface relies on the presence of a carboxy-terminal di-leucine-based signal (1). ENPP1 plays important roles in bone mineralization and soft tissue calcification (2-5). Mutations in the corresponding gene cause generalized arterial calcification in infancy (GACI) and idiopathic infantile arterial calcification (IIAC) (6,7). ENPP1 inhibits insulin receptor function and overexpression of this enzyme causes insulin resistance and glucose intolerance in mice (8,9). Genetic variants of ENPP1 have been associated with obesity and type 2 diabetes (10-12).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n1 ectonucleotide pyrophosphatase\/phosphodiesterase 1; 4833416E15Rik; AI428932; Alkaline phosphodiesterase I; C76301; CD203c; E-N; E-NPP 1; E-NPP1; ectonucleotide pyrophosphatase\/phosphodiesterase 1; Ectonucleotide pyrophosphatase\/phosphodiesterase family member 1; Ectonucleotide pyrophosphatase\/phosphodiesterase family member 1, secreted form; Enpp1; Ly-4; Ly-41; Lymphocyte antigen 41; M6S1; NPP1; NPPase; Npps; Nucleotide diphosphatase; Nucleotide pyrophosphatase; OTTMUSP00000021307; PC-; PC-1; Pc1; Pca; Pca-1; Pdnp1; Phosphodiesterase I\/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1; tiptoe walking; ttw; twy\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M R\nSENSITIVITY: Endogenous\nMW (kDa): 110\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800094199977,"sku":"40036S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-40036s","provider":"Iright","version":"1.0","type":"link"}