{"product_id":"cst-40165t","title":"CST,  40165T, PPP1R17 (F3O5C) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying GSBS mouse. Validated for WB,IP,IHC,IF. Available in 2 sizes. Highly specific and rigorously validated in-house, PPP1R17 (F3O5C) Rabbit Monoclonal Antibody (CST #40165) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\nImmunohistochemistry (Paraffin): 1:800 - 1:3200\nImmunofluorescence (Frozen): 1:6400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunohistochemistry (Paraffin), Immunofluorescence (Frozen)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPPP1R17 (F3O5C) Rabbit Monoclonal Antibody recognizes endogenous levels of total PPP1R17 protein. Staining of uncertain specificity was observed in adipose tissue, intercalated discs of the heart, and kidney proximal tubules by immunohistochemistry.\nSpecies Reactivity: Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse PPP1R17 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nProtein phosphatase 1 regulatory subunit 17 (PPP1R17) inhibits phosphatase activities of protein phosphatase type 1 (PP1) and protein phosphatase type 2A (PP2A) complexes (1). Its expression in the cerebellum is restricted to Purkinje cells, where it can be used as a marker for this cerebellar cell type (2). PPP1R17 expression has also been found in a subpopulation of neurons in the dorsomedial hypothalamus (DMH) that regulate restriction of food intake, aging, and longevity in mice (3,4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nG substrate; G-subst; G-substrate; Gsbs; Ppp1r17; Ppp1r2; PPR17; Protein phosphatase 1 regulatory subunit 17; protein phosphatase 1, regulatory (inhibitor) 2; protein phosphatase 1, regulatory subunit 17\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M R\nSENSITIVITY: Endogenous\nMW (kDa): 25\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800094527657,"sku":"40165T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-40165t","provider":"Iright","version":"1.0","type":"link"}