{"product_id":"cst-40180s","title":"CST,  40180S, PJA2 Antibody","description":"Polyclonal Antibody for studying PJA2. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, PJA2 Antibody (CST #40180) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPJA2 Antibody recognizes endogenous levels of total PJA2 protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly332 of human PJA2 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nPraja-2 (PJA2\/RNF131) is a RING-H2-type E3 ubiquitin ligase. PJA2 is highly expressed in neural tissue and research studies have shown that PJA2 plays a role modulating synaptic archictecture and long-term memory by promoting the ubiquitin-dependent proteolysis of NOGO-A and PKA regulatory subunits (1,2). Research studies have also shown that PJA2 sustains gliobastoma growth by driving the ubiquitin-dependent proteasomal degradation of MOB, which inactivates the LATS tumor suppressor kinase of the Hippo pathway (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nE3 ubiquitin-protein ligase Praja-2; KIAA0438; Neurodap1; PJA2; praja 2, RING-H2 motif containing; praja ring finger 2; praja ring finger 2, E3 ubiquitin protein ligase; praja ring finger ubiquitin ligase 2; Praja2; RING finger protein 131; RING-type E3 ubiquitin transferase Praja-2; RNF131\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 150\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799476097193,"sku":"40180S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-40180s","provider":"Iright","version":"1.0","type":"link"}