{"product_id":"cst-40838t","title":"CST,  40838T, ERCC1 Isoform 3 (E6R3Q) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ERCC1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, ERCC1 Isoform 3 (E6R3Q) Rabbit Monoclonal Antibody (CST #40838) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nERCC1 Isoform 3 (E6R3Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total ERCC1 isoform 3 protein. This antibody does not cross-react with ERCC1 isoforms 1, 2, or 4.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg283 of human ERCC1 isoform 3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nDNA repair systems operate in all living cells to manage a variety of DNA lesions. Nucleotide excision repair (NER) is implemented in cases where bulky helix-distorting lesions occur, such as those brought about by UV and certain chemicals (1). Excision Repair Cross Complementing 1 (ERCC1) forms a complex with ERCC4\/XPF, which acts as the 5' endonuclease required to excise the lesion (2). ERCC1-XPF is also required for repair of DNA interstrand crosslinks (ICLs) (3) and involved in repair of double strand breaks (4). Research studies have shown that expression of ERCC1 is related to survival rate and response to chemotherapeutic drugs in several human cancers including non-small cell lung cancer (NSCLC) (5,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCOFS4; DNA excision repair protein ERCC-1; ERCC excision repair 1, endonuclease non-catalytic subunit; ERCC1; excision repair cross-complementation group 1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); RAD10; UV20\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 41\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799481995433,"sku":"40838T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-40838t","provider":"Iright","version":"1.0","type":"link"}