{"product_id":"cst-40876s","title":"CST,  40876S, S100A9 (D3U8M) Rabbit Monoclonal Antibody (Alexa Fluor® 750 Conjugate)","description":"Monoclonal Antibody for studying S100A9 mouse. Validated for Immunohistochemistry (Paraffin),Flow Cytometry (Fixed\/Permeabilized). Highly specific and rigorously validated in-house, S100A9 (D3U8M) Rabbit Monoclonal Antibody (Alexa Fluor\u003csup\u003e®\u003c\/sup\u003e 750 Conjugate) (CST #40876) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nImmunohistochemistry (Paraffin): 1:50 - 1:200\nFlow Cytometry (Fixed\/Permeabilized): 1:800\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg\/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Immunohistochemistry (Paraffin), Flow Cytometry (Fixed\/Permeabilized)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nS100A9 (D3U8M) Rabbit Monoclonal Antibody (Alexa Fluor\nSpecies Reactivity: Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn98 of mouse S100A9 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nS100A8 and S100A9 are calcium-binding proteins that form a noncovalent heterodimer present in monocytes, neutrophils, macrophages, and some epithelial cells (1,2). S100A8 and S100A9 are secreted by a tubulin-dependent mechanism during inflammatory conditions and have antimicrobial and chemotactic functions (3-5). Extracellular S100A8\/S100A9 also induces an inflammatory response in endothelial cells, including induction of proinflammatory chemokines and adhesion molecules and increased vascular permeability (6). S100A8\/S100A9 induces and recruits myeloid-derived suppressor cells (MDSC) in tumor-bearing mice (7). MDSC produce additional S100A8\/S100A9 themselves, resulting in a positive feedback mechanism that sustains MDSC accumulation (7). S100A8\/S100A9 is also highly expressed in psoriatic skin, where it directly upregulates transcription of complement protein C3, which contributes to disease (8). In addition, tumor-infiltrating myeloid cells induce expression of S100A8 and S100A9 in cancer cells, which increases invasiveness and metastasis (9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n60B8A; 60B8Ag; AW546964; BEE22; Cag; Cagb; Calgranulin-B; GAG; GAGB; L1Ag; Leukocyte L1 complex heavy chain; Migration inhibitory factor-related protein 14; MRP; MRP-14; Mrp14; p14; Protein S100-A9; S100 calcium binding protein A9 (calgranulin B); S100 calcium-binding protein A9; S100 calcium-binding protein A9 (calgranulin B); S100a9; S10A9\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M R\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800395698345,"sku":"40876S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-40876s","provider":"Iright","version":"1.0","type":"link"}