{"product_id":"cst-4142s","title":"CST,  4142S, RIP2 (D10B11) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying RIP2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, RIP2 (D10B11) Rabbit Monoclonal Antibody (CST #4142) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nRIP2 (D10B11) Rabbit Monoclonal Antibody recognizes endogenous levels of total RIP2 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human RIP2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nReceptor Interacting Protein 2 (RIP2) is a serine\/threonine kinase with a carboxy-terminal caspase activation and recruitment domain (CARD). Association of RIP2 with the tumor necrosis factor receptor (TNFR) causes activation of NF-κB and induction of apoptosis (1-3). Expression of RIP2 is induced in macrophages upon exposure to bacterial cell wall components, such as LPS. RIP2-deficient mouse models demonstrate that this kinase integrates and transduces signals for both the innate and adaptive immune system (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; CARD3; CARDIAK; CCK; GIG30; growth-inhibiting gene 30; receptor interacting protein 2; receptor interacting serine\/threonine kinase 2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; Receptor-interacting protein 2; receptor-interacting serine-threonine kinase 2; Receptor-interacting serine\/threonine-protein kinase 2; RICK; RIP-2; RIP-like-interacting CLARP kinase; RIP2; RIPK2; Tyrosine-protein kinase RIPK2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 62\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799486156969,"sku":"4142S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-4142s","provider":"Iright","version":"1.0","type":"link"}