{"product_id":"cst-4155s","title":"CST,  4155S, EPAC1 (5D3) Mouse Monoclonal Antibody","description":"Monoclonal Antibody for studying Epac1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, EPAC1 (5D3) Mouse Monoclonal Antibody (CST #4155) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nEPAC1 (5D3) Mouse Monoclonal Antibody detects endogenous levels of total Epac1 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a recombinant fragment of human Epac1.\n\u003cb\u003eBackground\u003c\/b\u003e\nEPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA) (reviewed in 1). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation (2), exocytosis (3), insulin signaling (4), axon growth and guidance (5) and neurotransmitter release (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n9330170P05Rik; bcm910; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; CGEF1; EPAC; EPAC 1; EPAC1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; HSU79275; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; Rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; RAPGEF3; RPGF3\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 100\nSource\/Isotype: Mouse IgG2a","brand":"CST","offers":[{"title":"Default Title","offer_id":46799487598761,"sku":"4155S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-4155s","provider":"Iright","version":"1.0","type":"link"}