{"product_id":"cst-41666s","title":"CST,  41666S, p38 MAPK (D13E1) Rabbit Monoclonal Antibody (PE Conjugate)","description":"Monoclonal Antibody for studying p38-alpha MAPK\/p38-gamma MAPK\/p38-beta MAPK. Validated for Flow Cytometry (Fixed\/Permeabilized). Highly specific and rigorously validated in-house, p38 MAPK (D13E1) Rabbit Monoclonal Antibody (PE Conjugate) (CST #41666) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFlow Cytometry (Fixed\/Permeabilized): 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg\/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Flow Cytometry (Fixed\/Permeabilized)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\np38 MAPK (D13E1) Rabbit Monoclonal Antibody (PE Conjugate) recognizes endogenous levels of total p38α, β, or γ MAPK protein. This antibody conjugate does not recognize p38δ, SAPK\/JNK, or p44\/42 MAPK proteins.\nSpecies Reactivity: Human, Mouse, Rat, Hamster, Monkey, Bovine, Pig\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human p38 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\np38 MAP kinase (MAPK), also called RK (1) or CSBP (2), is the mammalian orthologue of the yeast HOG kinase that participates in a signaling cascade controlling cellular responses to cytokines and stress (1-4). Four isoforms of p38 MAPK, p38α, β, γ (also known as Erk6 or SAPK3), and δ (also known as SAPK4) have been identified. Similar to the SAPK\/JNK pathway, p38 MAPK is activated by a variety of cellular stresses, including osmotic shock, inflammatory cytokines, lipopolysaccharide (LPS), UV light, and growth factors (1-5). MKK3, MKK6, and SEK activate p38 MAPK by phosphorylation at Thr180 and Tyr182. Activated p38 MAPK has been shown to phosphorylate and activate MAPKAP kinase 2 (3) and to phosphorylate the transcription factors ATF-2 (5), Max (6), and MEF2 (5-8). SB203580 (4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-imidazole) is a selective inhibitor of p38 MAPK. This compound inhibits the activation of MAPKAPK-2 by p38 MAPK and subsequent phosphorylation of HSP27 (9). SB203580 inhibits p38 MAPK catalytic activity by binding to the ATP-binding pocket, but does not inhibit phosphorylation of p38 MAPK by upstream kinases (10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCSAID-binding protein; Csaids binding protein; CSBP; CSBP1; CSBP2; CSPB1; cytokine suppressive anti-inflammatory drug binding protein; Cytokine suppressive anti-inflammatory drug-binding protein; ERK-6; ERK3; ERK6; EXIP; Extracellular signal-regulated kinase 6; MAP kinase 11; MAP kinase 12; MAP kinase 14; MAP kinase MXI2; MAP kinase p38 alpha; MAP kinase p38 beta; MAP kinase p38 gamma; MAPK 11; MAPK 12; MAPK 14; MAPK11; MAPK12; MAPK14; MAX-interacting protein 2; Mitogen-activated protein kinase 11; Mitogen-activated protein kinase 12; Mitogen-activated protein kinase 14; mitogen-activated protein kinase 3; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase p38 beta; Mitogen-activated protein kinase p38 gamma; mitogen-activated protein kinase p38-2; MK11; MK12; MK14; MXI2; p38; p38 MAP kinase; p38 mitogen activated protein kinase; p38-2; p38-alpha; P38A; p38ALPHA; p38alpha Exip; p38b; p38Beta; P38BETA2; P38G; P38GAMMA; PRKM11; PRKM12; PRKM14; PRKM15; RK; SAPK-3; SAPK2; SAPK2A; SAPK2B; SAPK3; Stress-activated protein kinase 2; stress-activated protein kinase 2A; Stress-activated protein kinase 2b; Stress-activated protein kinase 3; stress-activated protein kinase-2; stress-activated protein kinase-2b\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Hm Mk B Pg\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800398123177,"sku":"41666S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-41666s","provider":"Iright","version":"1.0","type":"link"}