{"product_id":"cst-41798s","title":"CST,  41798S, Nectin-4\/PVRL4 (E5Q1W) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Nectin 4. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Nectin-4\/PVRL4 (E5Q1W) Rabbit Monoclonal Antibody (CST #41798) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNectin-4\/PVRL4 (E5Q1W) Rabbit Monoclonal Antibody recognizes endogenous levels of total Nectin-4\/PVRL4 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr283 of human Nectin-4\/PVRL4 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nNectin-4\/poliovirus receptor-related 4 (PVRL4) is a type-I transmembrane glycoprotein that belongs to the immunoglobulin superfamily and promotes cell-cell adhesion by serving as a major component of adherens junctions (1-3). The extracellular domain of Nectin-4, which contains an Ig variable-like domain (V) and two Ig constant-like domains (C), mediates binding to the measles virus (4) and to neighboring cells through heterophilic interactions with Nectin-1 (5,6). Unlike other nectin family members, which are widely expressed in adult tissues, Nectin-4 expression in humans is largely restricted to the placenta (7). Research studies have demonstrated that Nectin-4 is overexpressed in a variety of human solid tumors of the pancreas (8), breast (9,10), lung (11), and ovary (12). Due to its restricted expression pattern in normal human tissues, Nectin-4 may serve as a novel diagnostic and therapeutic target for a variety of human tumors.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nEDSS1; Ig superfamily receptor LNIR; LNIR; NECT4; nectin 4; Nectin cell adhesion molecule 4; Nectin-4; NECTIN4; poliovirus receptor-related 4; Poliovirus receptor-related protein 4; Processed poliovirus receptor-related protein 4; PRR4; PVRL4\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 62, 75\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799491334313,"sku":"41798S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-41798s","provider":"Iright","version":"1.0","type":"link"}