{"product_id":"cst-41910t","title":"CST,  41910T, Spi-C (E7V7F) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SPIC mouse. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Spi-C (E7V7F) Rabbit Monoclonal Antibody (CST #41910) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSpi-C (E7V7F) Rabbit Monoclonal Antibody recognizes overexpressed levels of total Spi-C protein. This antibody detects a 70 kDa band of unknown origin in some cell lines.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala205 of mouse Spi-C protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSpi-C belongs to the erythroblast transformation-specific (ETS) domain family of transcription factors and binds to the purine-rich PU-box (1-3). Spi-C is a lineage-instructive factor involved in generating mature, specialized subsets of both myeloid and lymphoid cells (6). Spi-C is highly expressed by red pulp macrophages in the spleen, which are required for red blood cell recycling and iron homeostasis (4,6). Spi-C is also transiently expressed in B cells during specific stages of their development and regulates cell fate decisions at the pro-B to pre-B cell stage and plasma cell differentiation (1-3,6). Spi-C has also been shown to be a positive regulator that promotes osteoclast differentiation and function (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAU019198; C76795; Prf; Pu.1-related factor; Spi-C; Spi-C transcription factor (Spi-1\/PU.1 related); Spic; Transcription factor Spi-C\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Transfected Only\nMW (kDa): 25, 28\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800095609001,"sku":"41910T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-41910t","provider":"Iright","version":"1.0","type":"link"}