{"product_id":"cst-41983s","title":"CST,  41983S, MNX1\/HB9 (E3W8D) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MNX1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MNX1\/HB9 (E3W8D) Rabbit Monoclonal Antibody (CST #41983) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMNX1\/HB9 (E3W8D) Rabbit Monoclonal Antibody recognizes endogenous levels of total MNX1\/HB9 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser231 of human MNX1\/HB9 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMotor neuron and pancreas homeobox protein 1 (MNX1 or Homeobox protein HB9) is a homeobox transcription factor that has conserved functions in motor neuron differentiation and pancreas development. The mammalian central nervous system (CNS) is composed of specialized neurons, and the \u003cb\u003eSpecification\u003c\/b\u003e of neuronal identity in the CNS is determined early in development by spatially-specified expression of cell-intrinsic determinants, many of which are transcription factors (1). MNX1\/HB9 is one such transcription factor. In response to developmental signals, MNX1\/HB9 is expressed transiently to drive differentiation of ventral progenitor cells into somatic motor neurons (2,3). Mutations in the gene encoding human MNX1\/HB9 are linked to Currarino syndrome, a developmental disease caused by dorsal-ventral patterning defects resulting in presacral tumors, sacral agenesis, and anorectal malformation in patients suffering from this disease (4,5). Â\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nHB9; HLXB9; homeobox HB9; Homeobox protein HB9; HOXHB9; MNX1; motor neuron and pancreas homeobox 1; Motor neuron and pancreas homeobox protein 1; SCRA1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 55\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799492907177,"sku":"41983S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-41983s","provider":"Iright","version":"1.0","type":"link"}