{"product_id":"cst-42267s","title":"CST,  42267S, SRSF10 Antibody","description":"Polyclonal Antibody for studying SRSF10. Validated for Western Blotting. Highly specific and rigorously validated in-house, SRSF10 Antibody (CST #42267) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSRSF10 Antibody recognizes endogenous levels of total SRSF10 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His167 of human SRSF10 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nSerine\/arginine-rich splicing factor 10 (SRSF10), also known as TASR or SRp38, was initially described as a splicing factor associated with the FUS oncoprotein (1,2). Upon dephosphorylation, SRSF10 represses splicing to regulate numerous functions, including cell cycle, heat shock response, neurogenesis, and adipocyte differentiation (3-6). SRSF10 is affected by adenosine methylation, as it has been shown to be excluded from nuclear speckles by m6A-binding protein YTHDC1 (7). SRSF10 splicing repression has been implicated in colon and cervical cancer (8,9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n40 kDa SR-repressor protein; DKFZp686H0644; FLJ30749; FLJ43846; FUS interacting protein (serine-arginine rich) 1; FUS-interacting protein (serine-arginine rich) 2; FUS-interacting serine-arginine-rich protein 1; FUSIP1; FUSIP2; neural-salient SR protein; NSSR; PPP1R149; protein phosphatase 1, regulatory subunit 149; serine and arginine rich splicing factor 10; serine-arginine repressor protein (40 kDa); Serine\/arginine-rich splicing factor 10; SF13A; SFRS13; SFRS13A; Splicing factor SRp38; splicing factor, arginine\/serine-rich 13; Splicing factor, arginine\/serine-rich 13A; SR splicing factor 10; SRp38; SRrp40; SRS10; SRSF10; TASR; TASR1; TASR2; TLS-associated protein TASR; TLS-associated protein with Ser-Arg repeats; TLS-associated protein with SR repeats; TLS-associated serine-arginine protein; TLS-associated serine-arginine protein 1; TLS-associated serine-arginine protein 2; TLS-associated SR protein\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 40\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799495495849,"sku":"42267S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-42267s","provider":"Iright","version":"1.0","type":"link"}