{"product_id":"cst-42301t","title":"CST,  42301T, BARX1 (F2K3K) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying BARX1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, BARX1 (F2K3K) Rabbit Monoclonal Antibody (CST #42301) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nBARX1 (F2K3K) Rabbit Monoclonal Antibody recognizes endogenous levels of total BARX1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly245 of human BARX1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nBARX homeobox 1 (BARX1) is a transcription factor (TF) that was first isolated from mouse embryos and identified to function as a repressive TF by directly binding to the NCAM promoter and inhibiting its transcription (1). BARX1 also plays a key role in cellular differentiation and cytoskeletal remodeling in various tissues such as stomach, intestine, and spleen (2-4). Several studies have also established a key role for this TF in the proliferation and metastasis of many tumors. Namely, BARX1 was shown to promote the proliferation of oesophageal adenocarcinoma and renal cell carcinoma (5,6) and was identified as one of the top ten oncogenic TFs that are critical in non-small cell lung cancer (7). Moreover, silencing of BARX1 in endometrial carcinoma cells was shown to suppress ERK\/MEK signaling pathway activity and reduce cell viability (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBarH-like homeobox 1; BARX homeobox 1; BARX1; Homeobox protein BarH-like 1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 30\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799495790761,"sku":"42301T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-42301t","provider":"Iright","version":"1.0","type":"link"}