{"product_id":"cst-42437s","title":"CST,  42437S, Cav2.3\/CACNA1E Antibody","description":"Polyclonal Antibody for studying CACNA1E mouse. Validated for Western Blotting. Highly specific and rigorously validated in-house, Cav2.3\/CACNA1E Antibody (CST #42437) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCav2.3\/CACNA1E Antibody recognizes endogenous levels of total Cav2.3 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1039 of mouse Cav2.3 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nVoltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells. VSCCs are involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. Calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 is encoded by the gene (1,2). In the brain, Cav2.3 has been implicated in synaptic plasticity (3,4). Interestingly, Cav2.3 may contribute to some neurodegenerative diseases like Parkinson's disease (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nA430040I15; alp; alpha1E; BII; Brain calcium channel II; CAC1E; Cach6; Cacna1e; Cacnl1a6; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide, isoform 6; calcium channel, voltage-dependent, L type, alpha 1E subunit; calcium channel, voltage-dependent, R type, alpha 1E subunit; Cav2; Cav2.3; Cchr; Cchra1; Voltage-dependent R-type calcium channel subunit alpha-1E; Voltage-gated calcium channel subunit alpha Cav2.3\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 257\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799497298089,"sku":"42437S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-42437s","provider":"Iright","version":"1.0","type":"link"}