{"product_id":"cst-42477s","title":"CST,  42477S, UQCRFS1\/RISP (E6Q7L) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying RISP. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, UQCRFS1\/RISP (E6Q7L) Rabbit Monoclonal Antibody (CST #42477) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nUQCRFS1\/RISP (E6Q7L) Rabbit Monoclonal Antibody recognizes endogenous levels of total UQCRFS1\/RISP protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human UQCRFS1\/RISP protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nUbiquinol-cytochrome c reductase iron-sulfur subunit (UQCRFS1), also known as Rieske iron-sulfur protein (RISP), is a component of Complex III in the mitochondrial electron transport chain. UQCRFS1\/RISP and two other subunits, cytochrome b (MT-CYB) and cytochrome c1 (CYC1), are essential for the catalytic activity of Complex III (1). Studies show that UQCRFS1\/RISP is required for fetal mouse hematopoietic stem cell differentiation and adult mouse hematopoietic stem cell quiescence (2). In addition, loss of UQCRFS1\/RISP decreases the strength of T cell receptor (TCR) signaling, indicating that this protein is critical for optimal TCR signaling (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n8 kDa subunit 9; Complex III subunit 5; Complex III subunit IX; Cytochrome b-c1 complex subunit 11; Cytochrome b-c1 complex subunit 5; Cytochrome b-c1 complex subunit 9; Cytochrome b-c1 complex subunit Rieske, mitochondrial; epididymis secretory sperm binding protein; MC3DN10; Rieske iron-sulfur protein; Rieske protein UQCRFS1; RIP1; RIS1; RISP; Su9; Subunit 9; Ubiquinol-cytochrome c reductase 8 kDa protein; Ubiquinol-cytochrome c reductase iron-sulfur subunit; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; UCRI; UQCR5; UQCRFS1; UQCRFS1 mitochondrial targeting sequence; UQCRFS1 MTS\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 23\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799497691305,"sku":"42477S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-42477s","provider":"Iright","version":"1.0","type":"link"}