{"product_id":"cst-42746t","title":"CST,  42746T, Layilin (E9U6M) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying LAYN. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Layilin (E9U6M) Rabbit Monoclonal Antibody (CST #42746) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLayilin (E9U6M) Rabbit Monoclonal Antibody recognizes endogenous levels of total Layilin protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human Layilin protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nLayilin (LAYN) is a single-pass type I integral membrane protein widely expressed by different cell types and tissues (1). LAYN is a hyaluronan receptor that directly interacts with several cytoskeletal-membrane linker molecules, including talin, merlin, and radixin (1-3). In both tumor and immune cell types, LAYN plays an important role in cell adhesion and motility, promoting cell spreading, migration, and infiltration (1,4-7). LAYN is involved in the tumor necrosis factor-α induced epithelial-mesenchymal transition of renal tubular epithelial cells (8), and also plays a critical role in HA35-induced intestinal epithelial tight junctions in inflammatory bowel disease (9). Lineage-specific deletion of LAYN on murine CD8  T cells reduced their accumulation in tumors and increased tumor growth (10). Multiple isoforms have been identified.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ30977; FLJ31092; Layilin; LAYN\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 43, 55\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799499952297,"sku":"42746T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-42746t","provider":"Iright","version":"1.0","type":"link"}